Rubredoxin—NAD(+) reductase

In enzymology, a rubredoxin-NAD⁺ reductase (EC 1.18.1.1) is an enzyme that catalyzes the chemical reaction.

rubredoxin-NAD+ reductase
Identifiers
EC no.	1.18.1.1
CAS no.	9032-27-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2 reduced rubredoxin + NAD⁺ + H⁺ $\rightleftharpoons$ 2 oxidized rubredoxin + NADH

The 3 substrates of this enzyme are reduced rubredoxin, NAD⁺, and H⁺, whereas its two products are oxidized rubredoxin and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD⁺ oxidoreductase. Other names in common use include rubredoxin reductase, rubredoxin-nicotinamide adenine dinucleotide reductase, dihydronicotinamide adenine dinucleotide-rubredoxin reductase, reduced nicotinamide adenine dinucleotide-rubredoxin reductase, NADH-rubredoxin reductase, rubredoxin-NAD reductase, NADH: rubredoxin oxidoreductase, DPNH-rubredoxin reductase, and NADH-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism. It has 2 cofactors: FAD and Iron.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1BFY.

See also

• Rubredoxin—NAD(P)(+) reductase

References

• Peterson JA, Kusunose M, Kusunose E, Coon MJ (1967). "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242 (19): 4334–40. doi:10.1016/S0021-9258(18)99543-8. PMID 4294330.
• "Enzymatic -oxidation. VI. Isolation of homogeneous reduced diphosphopyridine nucleotide-rubredoxin reductase". J. Biol. Chem. 247 (7): 2109–16. 1972. PMID 4335861.
• Ueda T, Coon MJ (1972). "Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation". J. Biol. Chem. 247 (16): 5010–6. doi:10.1016/S0021-9258(19)44932-6. PMID 4403503.
• Petitdemange H, Marczak R, Blusson H, Gay R (1979). "Isolation and properties of reduced nicotinamide adenine dinucleotiderubredoxin oxidoreductase of Clostridium acetobutylicum". Biochem. Biophys. Res. Commun. 91 (4): 1258–65. Bibcode:1979BBRC...91.1258P. doi:10.1016/0006-291X(79)91202-6. PMID 526302.