Poly(A) binding protein interacting protein 2B

PAIP2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JGN, 3KUS, 3KUT
Identifiers
Aliases	PAIP2B, poly(A) binding protein interacting protein 2B
External IDs	OMIM: 611018; MGI: 2386865; HomoloGene: 25798; GeneCards: PAIP2B; OMA:PAIP2B - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	71,227,103 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,808,723 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; internal globus pallidus; ; inferior ganglion of vagus nerve; ; C1 segment; ; Skeletal muscle tissue of rectus abdominis; ; subthalamic nucleus; ; dorsal motor nucleus of vagus nerve; ; middle frontal gyrus; ; substantia nigra; ; optic nerve;
	Top expressed in
	primary oocyte; ; lacrimal gland; ; parotid gland; ; zygote; ; secondary oocyte; ; sternocleidomastoid muscle; ; seminal vesicula; ; vestibular membrane of cochlear duct; ; extensor digitorum longus muscle; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; translation repressor activity, mRNA regulatory element binding;
Cellular component	cytoplasm;
Biological process	negative regulation of translational initiation; regulation of translation;
	Sources:Amigo / QuickGO
Orthologs
	400961
	232164
	ENSG00000124374
	ENSMUSG00000045896
	Q9ULR5
	Q91W45
	NM_020459
	NM_146169
	NP_065192
	NP_666281
	Wikidata
View/Edit Human	View/Edit Mouse

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene. ^[5] It is mainly expressed in the oocytes and fertilized eggs in mice.^[6]^[7]

Function

Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors .^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124374 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045896 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Poly(A) binding protein interacting protein 2B". Retrieved 2018-05-10.
↑ Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N (September 2010). "The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice". The Journal of Clinical Investigation. 120 (9): 3389–3400. doi:10.1172/JCI43350. PMC 2929737. PMID 20739757.
↑ "Mouse Gene Paip2b". UCSC genome browser. UC Santa Cruz.
↑ Derry MC, Yanagiya A, Martineau Y, Sonenberg N (2006). "Regulation of poly(A)-binding protein through PABP-interacting proteins". Cold Spring Harbor Symposia on Quantitative Biology. 71: 537–543. doi:10.1101/sqb.2006.71.061. PMID 17381337.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124374 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045896 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Poly(A) binding protein interacting protein 2B". Retrieved 2018-05-10.

[6] Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N (September 2010). "The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice". The Journal of Clinical Investigation. 120 (9): 3389–3400. doi:10.1172/JCI43350. PMC 2929737. PMID 20739757.

[7] "Mouse Gene Paip2b". UCSC genome browser. UC Santa Cruz.

[8] Derry MC, Yanagiya A, Martineau Y, Sonenberg N (2006). "Regulation of poly(A)-binding protein through PABP-interacting proteins". Cold Spring Harbor Symposia on Quantitative Biology. 71: 537–543. doi:10.1101/sqb.2006.71.061. PMID 17381337.

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