Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme[5][6][7][8][9][10][11] that in humans is encoded by the MASP2 gene.[12][13][14]
| Mannan-binding lectin-associated serine protease-2 | |||||||||
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| Identifiers | |||||||||
| EC no. | 3.4.21.104 | ||||||||
| CAS no. | 214915-16-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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| MASP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | MASP2, MAP19, MASP-2, MASP1P1, sMAP, mannan binding lectin serine peptidase 2, Mannan-binding lectin serine protease 2, MBL associated serine protease 2, MAP-2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605102; MGI: 1330832; HomoloGene: 4819; GeneCards: MASP2; OMA:MASP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
editThis enzyme catalyses the following chemical reaction
- Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)
This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases.[12][citation needed]
MASP-2 is involved in the complement system. MASP-2 is very similar to the C1s molecule, of the classical complement pathway, and they are thought to have a common evolutionary ancestor. When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b.
See also
edit- MASP1 (protein)
- Mannan-binding lectin
- Mannan-binding lectin pathway (lectin pathway)
References
edit- 1 2 3 GRCh38: Ensembl release 89: ENSG00000009724 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028979 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Matsushita M, Fujita T (December 1992). "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease". The Journal of Experimental Medicine. 176 (6): 1497–502. doi:10.1084/jem.176.6.1497. PMC 2119445. PMID 1460414.
- ↑ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature. 386 (6624): 506–10. Bibcode:1997Natur.386..506T. doi:10.1038/386506a0. PMID 9087411.
- ↑ Rossi V, Cseh S, Bally I, Thielens NM, Jensenius JC, Arlaud GJ (November 2001). "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2". The Journal of Biological Chemistry. 276 (44): 40880–7. doi:10.1074/jbc.M105934200. PMID 11527969.
- ↑ Ambrus G, Gál P, Kojima M, Szilágyi K, Balczer J, Antal J, Gráf L, Laich A, Moffatt BE, Schwaeble W, Sim RB, Závodszky P (February 2003). "Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments". Journal of Immunology. 170 (3): 1374–82. doi:10.4049/jimmunol.170.3.1374. PMID 12538697.
- ↑ Harmat V, Gál P, Kardos J, Szilágyi K, Ambrus G, Végh B, Náray-Szabó G, Závodszky P (October 2004). "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions". Journal of Molecular Biology. 342 (5): 1533–46. doi:10.1016/j.jmb.2004.07.014. PMID 15364579.
- ↑ Chen CB, Wallis R (June 2004). "Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases". The Journal of Biological Chemistry. 279 (25): 26058–65. doi:10.1074/jbc.M401318200. PMID 15060079.
- ↑ Teillet F, Dublet B, Andrieu JP, Gaboriaud C, Arlaud GJ, Thielens NM (March 2005). "The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases". Journal of Immunology. 174 (5): 2870–7. doi:10.4049/jimmunol.174.5.2870. PMID 15728497.
- 1 2 "Entrez Gene: mannan-binding lectin serine peptidase 2".
- ↑ Thiel S, Vorup-Jensen T, Stover CM, Schwaeble W, Laursen SB, Poulsen K, Willis AC, Eggleton P, Hansen S, Holmskov U, Reid KB, Jensenius JC (April 1997). "A second serine protease associated with mannan-binding lectin that activates complement". Nature. 386 (6624): 506–10. Bibcode:1997Natur.386..506T. doi:10.1038/386506a0. PMID 9087411. S2CID 4261967.
- ↑ Vorup-Jensen T, Jensenius JC, Thiel S (August 1998). "MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway". Immunobiology. 199 (2): 348–57. doi:10.1016/S0171-2985(98)80039-9. PMID 9777418.
Further reading
edit- Petersen SV, Thiel S, Jensenius JC (2001). "The mannan-binding lectin pathway of complement activation: biology and disease association". Mol. Immunol. 38 (2–3): 133–49. doi:10.1016/S0161-5890(01)00038-4. PMID 11532276.
- Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ (2009). "Common variation in genes related to innate immunity and risk of adult glioma". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. doi:10.1158/1055-9965.EPI-08-1041. PMC 2771723. PMID 19423540.
- McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF (2009). "Integrative predictive model of coronary artery calcification in atherosclerosis". Circulation. 120 (24): 2448–54. doi:10.1161/CIRCULATIONAHA.109.865501. PMC 2810344. PMID 19948975.
- Gulla KC, Gupta K, Krarup A, Gal P, Schwaeble WJ, Sim RB, O'Connor CD, Hajela K (2010). "Activation of mannan-binding lectin-associated serine proteases leads to generation of a fibrin clot". Immunology. 129 (4): 482–95. doi:10.1111/j.1365-2567.2009.03200.x. PMC 2842495. PMID 20002787.
- Cerhan JR, Novak AJ, Fredericksen ZS, Wang AH, Liebow M, Call TG, Dogan A, Witzig TE, Ansell SM, Habermann TM, Kay NE, Slager SL (2009). "Risk of non-Hodgkin lymphoma in association with germline variation in complement genes". Br. J. Haematol. 145 (5): 614–23. doi:10.1111/j.1365-2141.2009.07675.x. PMC 2820509. PMID 19344414.
- Wang Y, Yan J, Shi Y, Li P, Liu C, Ma Q, Yang R, Wang X, Zhu L, Yang X, Cao C (2009). "Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection". BMC Infect. Dis. 9 51. doi:10.1186/1471-2334-9-51. PMC 2683852. PMID 19405982.
- Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia". Hum. Immunol. 71 (7): 727–30. doi:10.1016/j.humimm.2010.04.004. PMC 2967770. PMID 20438785.
- Kocsis A, Kékesi KA, Szász R, Végh BM, Balczer J, Dobó J, Závodszky P, Gál P, Pál G (2010). "Selective inhibition of the lectin pathway of complement with phage display selected peptides against mannose-binding lectin-associated serine protease (MASP)-1 and -2: significant contribution of MASP-1 to lectin pathway activation". J. Immunol. 185 (7): 4169–78. doi:10.4049/jimmunol.1001819. hdl:10831/91219. PMID 20817870.
- Segat L, Milanese M, Pirulli D, Trevisiol C, Lupo F, Salizzoni M, Amoroso A, Crovella S (2009). "Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients". J. Gastroenterol. Hepatol. 24 (12): 1840–6. doi:10.1111/j.1440-1746.2009.06009.x. PMID 19817957. S2CID 205464848.
- Smithson A, Perello R, Aibar J, Espinosa G, Tassies D, Freire C, Castro P, Suarez B, Lozano F, Nicolas JM (2010). "Genotypes coding for low serum levels of mannose-binding lectin are underrepresented among individuals suffering from noninfectious systemic inflammatory response syndrome". Clin. Vaccine Immunol. 17 (3): 447–53. doi:10.1128/CVI.00375-09. PMC 2837953. PMID 20042521.
- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Ytting H, Christensen IJ, Steffensen R, Alsner J, Thiel S, Jensenius JC, Hansen U, Nielsen HJ (2011). "Mannan-binding lectin (MBL) and MBL-associated serine protease 2 (MASP-2) genotypes in colorectal cancer". Scand. J. Immunol. 73 (2): 122–7. doi:10.1111/j.1365-3083.2010.02480.x. PMID 21198752.
- Vallès X, Roca A, Lozano F, Morais L, Suárez B, Casals F, Mandomando I, Sigaúque B, Nhalungo D, Esquinas C, Quintó L, Alonso PL, Torres A (2010). "Serotype-specific pneumococcal disease may be influenced by mannose-binding lectin deficiency". Eur. Respir. J. 36 (4): 856–63. doi:10.1183/09031936.00171409. PMID 20150204.
- de Rooij BJ, van Hoek B, ten Hove WR, Roos A, Bouwman LH, Schaapherder AF, Porte RJ, Daha MR, van der Reijden JJ, Coenraad MJ, Ringers J, Baranski AG, Hepkema BG, Hommes DW, Verspaget HW (2010). "Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation". Hepatology. 52 (3): 1100–10. doi:10.1002/hep.23782. PMID 20593422. S2CID 205875239.
- Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD (2010). "Risk of meningioma and common variation in genes related to innate immunity". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. doi:10.1158/1055-9965.EPI-09-1151. PMC 3169167. PMID 20406964.
- Liu JL, Cao C, Ma QJ (2009). "[Study on interaction between SARS-CoV N and MAP19]". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 25 (9): 777–9. PMID 19737459.
- St Swierzko A, Cedzynski M, Domzalska-Popadiuk I, MacDonald SL, Borkowska-Klos M, Atkinson AP, Szala A, Jopek A, Jensenius JC, Kawakami M, Szczapa J, Matsushita M, Szemraj J, Turner ML, Kilpatrick DC (2009). "Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations". Mol. Immunol. 46 (8–9): 1696–701. doi:10.1016/j.molimm.2009.02.022. PMID 19307021.
- Vallès X, Sarrias MR, Casals F, Farnós M, Piñer R, Suárez B, Morais L, Mandomando I, Sigaúque B, Roca A, Alonso PL, Torres A, Thielens NM, Lozano F (2009). "Genetic and structural analysis of MBL2 and MASP2 polymorphisms in south-eastern African children". Tissue Antigens. 74 (4): 298–307. doi:10.1111/j.1399-0039.2009.01328.x. PMID 19775369.
- Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
External links
edit- MASP+Proteases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Mannan-binding+lectin-associated+serine+protease-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
