Isoflavone 4'-O-methyltransferase (EC 2.1.1.46) is an enzyme that catalyzes a general chemical reaction that adds a methyl group to a specific phenolic oxygen in isoflavones, for example:
| Isoflavone 4'-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.46 | ||||||||
| CAS no. | 55071-80-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In this example, the methylation reaction converts daidzein to formomonetin. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme can act on other isoflavones such as genistein but flavanones such as naringenin are not substrates.[1][2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase. Other names in common use include 4'-hydroxyisoflavone methyltransferase, isoflavone methyltransferase, and isoflavone O-methyltransferase.[1]
References
edit- 1 2 Enzyme 2.1.1.46 at KEGG Pathway Database.
- ↑ Wengenmayer H, Ebel J, Grisebach H (1974). "Purification and properties of a S-adenosylmethionine: isoflavone 4'-O-methyltransferase from cell suspension cultures of Cicer arietinum L". Eur. J. Biochem. 50 (1): 135–43. doi:10.1111/j.1432-1033.1974.tb03881.x. PMID 4452353.
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