English: The hantavirus life cycle consists of ten major steps, that are necessary to release new viral particles. Hantaviruses bind to their respective receptor on the surface of the host cell with the envelope glycoproteins Gn/Gc. Entry of the viral particles occur either via clathrin-dependent (OWHVs, e.g., PUUV) or clathrin-independent endocytosis (NWHVs). The viral glycoproteins dissociate from the cellular receptors and traffic through the endocytic pathway. Low pH of the endosomes and other cellular factors trigger a membrane-fusion process between viral and cellular membranes. Viruses are uncoated and viral genome and proteins are released into the cytoplasm. Viral RNA (vRNA) is transcribed by the RNA-dependent RNA polymerase (RdRp) and mRNA is subsequently translated into different viral proteins, which are necessary to hijack the host cell machinery.] vRNA is synthesized and new viral particles are assembled at the [9a] Golgi-complex (OWHVs, e.g., PUUV) or at the cell membrane (NWHVs). Viral particles are released by fusion of the Golgi-complex (OWHVs, e.g., PUUV) or viral vesicle (NWHVs) with host cell membrane. E.E., early endosome; L.E., late endosome.