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Summary
Summary
| Description |
English: When a non-retroviral virus infects a cell, the viral RNA is released and double stranded RNA (dsRNA) intermediates are produced. Viral dsRNA is then used as a template to produce viral DNA (vDNA) by the reverse transcriptase activity of retrotransposon elements. vDNA integrates into the host cell genome, probably by transposition activity of retrotransposons, becoming a NIRVS. NIRVS is then transcribed either into siRNAs or piRNAs to inhibit the viral RNA after association with the RISC complex or into mRNA, and translated into a dominant negative form protein, that can alter the viral replication by several ways. For example, by inhibiting the viral replication complex or viral assembly. |
| Date | |
| Source | https://www.tandfonline.com/doi/figure/10.1080/22221751.2019.1599302?scroll=top&needAccess=true# |
| Author | Vincent Houé, Mariangela Bonizzoni &Anna-Bella Failloux |
Licensing
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- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
Licensing
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 03:17, 24 May 2026 | | 1,500 × 1,150 (1.46 MB) | Nahleghini | recropped |
| 03:09, 24 May 2026 |  | 1,500 × 1,150 (1.62 MB) | Nahleghini | =={{int:filedesc}}== {{Information |description={{en|1=When a non-retroviral virus infects a cell, the viral RNA is released and double stranded RNA (dsRNA) intermediates are produced. Viral dsRNA is then used as a template to produce viral DNA (vDNA) by the reverse transcriptase activity of retrotransposon elements. vDNA integrates into the host cell genome, probably by transposition activity of retrotransposons, becoming a NIRVS. NIRVS is then transcribed either into siRNAs or piRNAs to inh... |
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