Collectin-12

Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene.

COLEC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OX8
Identifiers
Aliases	COLEC12, CLP1, NSR2, SCARA4, SRCL, collectin subfamily member 12
External IDs	OMIM: 607621; MGI: 2152907; HomoloGene: 34248; GeneCards: COLEC12; OMA:COLEC12 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) Band 18p11.32 Start 316,737 bp End 500,722 bp
Gene location (Mouse) Chr. Chromosome 18 (mouse) Band 18|18 A1 Start 9,707,595 bp End 9,882,644 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint tibia synovial membrane tendon of biceps brachii retinal pigment epithelium placenta skin of hip periodontal fiber pericardium cartilage tissue Top expressed in basilar part of occipital bone mesothelium of peritoneum sphenoid bone calvaria basisphenoid pericardium vestibular sensory epithelium external carotid artery rib pleura More reference expression data BioGPS n/a
Gene ontology Molecular function pattern recognition receptor activity galactose binding metal ion binding low-density lipoprotein particle binding scavenger receptor activity carbohydrate binding Cellular component integral component of membrane endocytic vesicle membrane collagen membrane plasma membrane extracellular space extracellular matrix Biological process defense response positive regulation of cell adhesion molecule production carbohydrate mediated signaling receptor-mediated endocytosis immune response cellular response to exogenous dsRNA phagocytosis, recognition innate immune response toll-like receptor 3 signaling pathway protein homooligomerization regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81035 140792 Ensembl ENSG00000158270 ENSMUSG00000036103 UniProt Q5KU26 Q8K4Q8 RefSeq (mRNA) NM_030781 NM_130386 NM_130449 RefSeq (protein) NP_569057 NP_569716 Location (UCSC) Chr 18: 0.32 – 0.5 Mb Chr 18: 9.71 – 9.88 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, May 2018].

Further reading

• Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y, Wakamiya N, Hata A (2003). "Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene". J. Hum. Genet. 48 (2): 82–5. doi:10.1007/s100380300011. PMID 12601552.
• Yoshida T, Tsuruta Y, Iwasaki M, Yamane S, Ochi T, Suzuki R (March 2003). "SRCL/CL-P1 recognizes GalNAc and a carcinoma-associated antigen, Tn antigen". J. Biochem. 133 (3): 271–7. doi:10.1093/jb/mvg037. PMID 12761161.
• Coombs PJ, Graham SA, Drickamer K, Taylor ME (June 2005). "Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands". J. Biol. Chem. 280 (24): 22993–9. doi:10.1074/jbc.M504197200. hdl:11858/00-001M-0000-0011-5639-F. PMID 15845541.
• Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S (June 2008). "Expression and tissue localization of collectin placenta 1 (CL-P1, SRCL) in human tissues". Mol. Immunol. 45 (11): 3278–88. doi:10.1016/j.molimm.2008.02.018. PMID 18423602.
• Jang S, Ohtani K, Fukuoh A, Yoshizaki T, Fukuda M, Motomura W, Mori K, Fukuzawa J, Kitamoto N, Yoshida I, Suzuki Y, Wakamiya N (February 2009). "Scavenger receptor collectin placenta 1 (CL-P1) predominantly mediates zymosan phagocytosis by human vascular endothelial cells". J. Biol. Chem. 284 (6): 3956–65. doi:10.1074/jbc.M807477200. PMID 19073604.
• Samsen A, Bogoevska V, Klampe B, Bamberger AM, Lucka L, Horst AK, Nollau P, Wagener C (January 2010). "DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools". Eur. J. Cell Biol. 89 (1): 87–94. doi:10.1016/j.ejcb.2009.11.018. PMID 20034698.
• Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Graham SA, Antonopoulos A, Hitchen PG, Haslam SM, Dell A, Drickamer K, Taylor ME (July 2011). "Identification of neutrophil granule glycoproteins as Lewis(x)-containing ligands cleared by the scavenger receptor C-type lectin". J. Biol. Chem. 286 (27): 24336–49. doi:10.1074/jbc.M111.244772. PMC 3129213. PMID 21561871.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.