2CT2-5-EtO, also known as 4-ethylthio-2-methoxy-5-ethoxyphenethylamine or as Forever Yours, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T-2.[1][2][3] It is the derivative of 2C-T-2 in which the methoxy group at the 5 position has been replaced with an ethoxy group.[1][2][3]
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| Clinical data | |
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| Other names | 2CT2-5EtO; 2CT2-5-ETO; 2CT2-5ETO; 2-Methoxy-4-ethylthio-5-ethoxyphenethylamine; 4-Ethylthio-2-methoxy-5-ethoxyphenethylamine; Forever Yours |
| Routes of administration | Oral[1][2][3] |
| Drug class | Psychoactive drug |
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| Pharmacokinetic data | |
| Onset of action | "Slow" or "gentle"; 3–4 hours (peak)[1] |
| Duration of action | 16–24 hours[1][2][3] |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C13H21NO2S |
| Molar mass | 255.38 g·mol−1 |
| 3D model (JSmol) | |
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According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-5-EtO's dose is 20 mg orally and its duration is 16 to 24 hours.[1][2][3] Its onset is said to be "slow" and "gentle", with peak effects occurring after 3 or 4 hours, and it is said to be very long-lived.[1] The effects of 2CT2-5-EtO have been reported to include flooding of thoughts, easy conversation, insights, and feeling drained in the following day or two.[1] Occasionally, a sedative was given to counteract its effects at the 16-hour point and allow for sleep, but with some intoxication still present the next day.[1] The drug's potency is similar to that of 2C-T-2, but it is much longer-lasting.[1][2][3] Due to its long duration, 2CT2-5-EtO was given the nickname "Forever Yours".[1]
The chemical synthesis of 2CT2-5-EtO has been described.[1]
2CT2-5-EtO was first described in the literature by Shulgin in PiHKAL in 1991.[1] It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin.[2][4][5][6][7] The drug is a controlled substance in Canada under phenethylamine blanket-ban language.[8]
See also
editReferences
edit- 1 2 3 4 5 6 7 8 9 10 11 12 13 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "The 5-EtO-homologue of 2C-T-2 is 5-ethoxy-4-ethylthio-2-methoxyphenethylamine, or 2CT2-5ETO. The benzaldehyde (5-ethoxy-4-ethylthio-2-methoxybenzaldehyde) had a melting point of 49 °C, but it was impure. The nitrostyrene intermediate melted at 107-108 °C, and the final hydrochloride had a melting point of 180 °C. At levels of 20 milligrams, there was a slow, gentle climb to a full effect at the third or fourth hour. The flooding of thoughts and easy conversation lasted for many hours, and on some occasion a sedative was needed at the 16 hour point. There was a feeling of being drained for the following day or two. Some intoxication was still noted in the second day. Again it is true here, as had been stated as a generality, that the 5-Tweetio analogues have potencies similar to that of the parent compound, but show a much longer duration. The nickname of "forever yours" had been applied. There may indeed be insight, but 24 hours' worth is an awful lot of insight."
- 1 2 3 4 5 6 7 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
- 1 2 3 4 5 6 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
- ↑ "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
- ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
- ↑ Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
- ↑ Nez H, Lemaire D (Lazar) (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
- ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.