24-hydroxycholesterol 7alpha-hydroxylase
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In enzymology, a 24-hydroxycholesterol 7alpha-hydroxylase (EC 1.14.14.26) is an enzyme that catalyzes the chemical reaction
| 24-hydroxycholesterol 7alpha-hydroxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.26 | ||||||||
| CAS no. | 288309-90-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
-7α,24-dihydroxycholesterol.svg)
The four substrates of this enzyme are 24S-hydroxycholesterol, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are (24S)-7α,24-dihydroxycholesterol, oxidised NADP+, and water.[1][2][3]
This enzyme is a cytochrome P450-type oxidoreductase, acting on paired donors, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is (24R)-cholest-5-ene-3beta,24-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating). Other names in common use include 24-hydroxycholesterol 7alpha-monooxygenase, CYP39A1, and CYP39A1 oxysterol 7alpha-hydroxylase.[4]
See also
editReferences
edit- ↑ Li-Hawkins J, Lund EG, Bronson AD, Russell DW (2000). "Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol". J. Biol. Chem. 275 (22): 16543–9. doi:10.1074/jbc.M001810200. PMID 10748047.
- ↑ Ikeda H, Ueda M, Ikeda M, Kobayashi H, Honda Y (2003). "Oxysterol 7alpha-hydroxylase (CYP39A1) in the ciliary nonpigmented epithelium of bovine eye". Lab. Invest. 83 (3): 349–55. doi:10.1097/01.lab.0000059933.35157.40. PMID 12649335.
- ↑ Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708.
- ↑ Enzyme 1.14.14.26 at KEGG Pathway Database.
External links
edit- 24-hydroxycholesterol+7alpha-hydroxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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