| Date | Time | Opponent | Rank | Site | TV | Result | Attendance |
|---|
| September 4 | 7:00 p.m. | at Texas Southern | | | ESPN3 | W 40–17 | 18,297 |
| September 11 | 7:00 p.m. | at Incarnate Word* | | | ESPN+ | L 9–40 | 2,517 |
| September 18 | 6:00 p.m. | Houston Baptist* | | | | W 37–27 | 8,476 |
| September 25 | 4:00 p.m. | vs. Grambling State | | | | W 24–10 | 26,198 |
| 6:00 p.m. | Arkansas–Pine Bluff | | - Panther Stadium at Blackshear Field
- Prairie View, TX
| ESPNU | W 27–17 | 8,467 |
| October 16 | 3:00 p.m. | at Bethune–Cookman | | | YouTube | W 35–29 | 3,267 |
| October 23 | 6:00 p.m. | at Southern | | | ESPN3 | W 48–21 | 24,580 |
| November 6 | 2:00 p.m. | Alabama State | | - Panther Stadium at Blackshear Field
- Prairie View, TX
| | W 24–20 | 6,107 |
| November 13 | 2:00 p.m. | at Alcorn State | No. 24 | | | L 29–31 | 0 |
| November 20 | 11:00 a.m. | at No. 16 (FBS) Texas A&M* | | | ESPN+/SECN+ | L 3–52 | 98,251 |
| November 27 | 2:00 p.m. | Mississippi Valley State | | - Panther Stadium at Blackshear Field
- Prairie View, TX
| ESPN3 | L 19–24 | 724 |
| December 4 | 3:00 p.m. | at No. 15 Jackson State | | | ESPN2 | L 10–27 | 50,128 |
|
[1]
Prairie View A&M at Texas Southern
| Team |
1 |
2 | 3 | 4 | Total |
| • Panthers |
6 |
14 | 10 | 10 |
40 |
| Tigers |
3 |
0 | 7 | 7 |
17 |
- Date: September 4, 2021
- Location: BBVA Stadium
Houston, TX - Game start: 7:00 p.m. CDT
- Elapsed time:
- Game attendance:
- Game weather: • Weather: TBD • Wind: TBD
- Referee:
- TV announcers (ESPN3):
| Statistics | Prairie View A&M | Texas Southern |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Texas Southern | Passing | | |
| Rushing | | |
| Receiving | | |
Prairie View A&M at Incarnate Word
| Team |
1 |
2 | 3 | 4 | Total |
| Panthers |
0 |
0 | 0 | 9 |
9 |
| • Cardinals |
17 |
13 | 10 | 0 |
40 |
- Date: September 11, 2021
- Location: Gayle and Tom Benson Stadium
San Antonio, TX - Game start: 7:00 p.m. CDT
- Elapsed time:
- Game attendance: 2,517
- Game weather: 88 °F (31 °C) • Weather: Clear • Wind: E 10 mph
- Referee: Ed Bourgeois
- TV announcers (ESPN+): David Saltzman (play-by-play), Taylor McHargue (analyst)
| Statistics | Prairie View A&M | Incarnate Word |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Incarnate Word | Passing | | |
| Rushing | | |
| Receiving | | |
Houston Baptist at Prairie View A&M
| Team |
1 |
2 | 3 | 4 | Total |
| Huskies |
21 |
3 | 3 | 0 |
27 |
| • Panthers |
20 |
3 | 7 | 7 |
37 |
| Statistics | Houston Baptist | Prairie View A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Houston Baptist | Passing | | |
| Rushing | | |
| Receiving | | |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
Grambling State vs. Prairie View A&M
| Team |
1 |
2 | 3 | 4 | Total |
| Tigers |
0 |
7 | 3 | 0 |
10 |
| • Panthers |
7 |
3 | 7 | 7 |
24 |
- Date: September 25, 2021
- Location: Cotton Bowl
Dallas, TX - Game start: 4:00 p.m. CDT
- Elapsed time:
- Game attendance:
- Referee:
- TV announcers ( ):
| Statistics | Grambling State | Prairie View A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Grambling State | Passing | | |
| Rushing | | |
| Receiving | | |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
Arkansas–Pine Bluff at Prairie View A&M
| Team |
1 |
2 | 3 | 4 | Total |
| Golden Lions |
3 |
6 | 0 | 8 |
17 |
| • Panthers |
14 |
7 | 6 | 0 |
27 |
| Statistics | Arkansas–Pine Bluff | Prairie View A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Arkansas–Pine Bluff | Passing | | |
| Rushing | | |
| Receiving | | |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
Prairie View A&M at Bethune–Cookman
| Team |
1 |
2 | 3 | 4 | Total |
| • Panthers |
7 |
7 | 7 | 14 |
35 |
| Wildcats |
0 |
8 | 7 | 14 |
29 |
| Statistics | Prairie View A&M | Bethune–Cookman |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Bethune–Cookman | Passing | | |
| Rushing | | |
| Receiving | | |
Prairie View A&M at Southern
| Team |
1 |
2 | 3 | 4 | Total |
| • Panthers |
7 |
7 | 17 | 17 |
48 |
| Jaguars |
0 |
7 | 7 | 7 |
21 |
- Date: October 23, 2021
- Location: A. W. Mumford Stadium
Baton Rouge, LA - Game start: 6:00 p.m. CDT
- Elapsed time: 3 hours and 17 minutes
- Game attendance: 24,580
- Game weather: 80 °F (27 °C) • Weather: Sunny • Wind: SE 9 MPH
- Referee: Tony Ross
- TV announcers (ESPN3):
| Statistics | Prairie View A&M | Southern |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Southern | Passing | | |
| Rushing | | |
| Receiving | | |
Alabama State at Prairie View A&M
| Team |
1 |
2 | 3 | 4 | Total |
| Hornets |
10 |
10 | 0 | 0 |
20 |
| • Panthers |
7 |
3 | 0 | 14 |
24 |
| Statistics | Alabama State | Prairie View A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Alabama State | Passing | | |
| Rushing | | |
| Receiving | | |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
Prairie View A&M at Alcorn State
| Team |
1 |
2 | 3 | 4 | Total |
| No. 24 Panthers |
6 |
3 | 7 | 13 |
29 |
| • Braves |
0 |
24 | 7 | 0 |
31 |
- Date: November 13, 2021
- Location: Casem-Spinks Stadium
Lorman, MS - Game start: 2:00 p.m. CST
- Elapsed time:
- Game attendance:
- Game weather: • Weather: TBD • Wind: TBD
- Referee:
- TV announcers ( ):
| Statistics | Prairie View A&M | Alcorn State |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Alcorn State | Passing | | |
| Rushing | | |
| Receiving | | |
At No. 16 (FBS) Texas A&M
edit
Prairie View A&M at Texas A&M
| Team |
1 |
2 | 3 | 4 | Total |
| Panthers |
0 |
0 | 3 | 0 |
3 |
| • No. 16 (FBS) Aggies |
21 |
17 | 7 | 7 |
52 |
| Statistics | Prairie View A&M | Texas A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |
| Texas A&M | Passing | | |
| Rushing | | |
| Receiving | | |
Mississippi Valley State
edit
Mississippi Valley State at Prairie View A&M
| Team |
1 |
2 | Total |
| Delta Devils |
|
|
0 |
| Panthers |
|
|
0 |
| Statistics | Mississippi Valley State | Prairie View A&M |
| First downs | | |
| Total yards | | |
| Rushing yards | | |
| Passing yards | | |
| Turnovers | | |
| Time of possession | | |
| Team | Category | Player | Statistics |
| Mississippi Valley State | Passing | | |
| Rushing | | |
| Receiving | | |
| Prairie View A&M | Passing | | |
| Rushing | | |
| Receiving | | |