Four-time defending champion Esther Vergeer defeated Daniela Di Toro in the final, 6–0, 6–0 to win the women's singles wheelchair tennis title at the 2010 US Open.
| Wheelchair women's singles | |
|---|---|
| 2010 US Open | |
| Champion |  Esther Vergeer |
| Runner-up |  Daniela Di Toro |
| Score | 6–0, 6–0 |
Seeds
edit- Esther Vergeer (champion)
- Sharon Walraven (semifinals)
Draw
editKey
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- ITF = ITF entry
- PR = Protected ranking
- SR = Special ranking
- SE = Special exempt
- JE = Junior exempt
- JR = Junior Accelerator Programme entrant
- CO = College Accelerator Programme entrant
- NG = Next Gen Accelerator Program entrant
- w/o = Walkover
- r = Retired
- d = Defaulted
Finals
edit| Quarterfinals | Semifinals | Finals | ||||||||||||||||||
| 1 | Esther Vergeer
| 7 | 7 | |||||||||||||||||
 Florence Alix-Gravellier
| 5 | 5 | ||||||||||||||||||
| 1 | Esther Vergeer
| 6 | 6 | |||||||||||||||||
| Jiske Griffioen
| 1 | 0 | ||||||||||||||||||
| Jiske Griffioen
| 6 | 6 | ||||||||||||||||||
| WC |  Mackenzie Soldan
| 1 | 1 | |||||||||||||||||
| 1 | Esther Vergeer
| 6 | 6 | |||||||||||||||||
| Daniela Di Toro
| 0 | 0 | ||||||||||||||||||
| Daniela Di Toro
| 6 | 7 | ||||||||||||||||||
| Aniek van Koot
| 3 | 62 | ||||||||||||||||||
| Daniela Di Toro
| 6 | 6 | ||||||||||||||||||
| 2 | Sharon Walraven
| 4 | 2 | |||||||||||||||||
 Annick Sevenans
| 4 | 3 | ||||||||||||||||||
| 2 | Sharon Walraven
| 6 | 6 | |||||||||||||||||