2-Me-DET

2-Me-DET
Clinical data
Other names	2-Methyl-DET; 2-Methyl-N,N-diethyltryptamine
Routes of; administration	Oral
Drug class	Psychoactive drug; Serotonergic psychedelic; Hallucinogen
ATC code	None;
Pharmacokinetic data
Duration of action	6–8 hours
Identifiers
	IUPAC name N,N-diethyl-2-(2-methyl-1H-indol-3-yl)ethanamine;
CAS Number	26628-88-6;
PubChem CID	33561;
ChemSpider	30962;
UNII	SSF4F77CV3;
CompTox Dashboard (EPA)	DTXSID30181174 ;
Chemical and physical data
Formula	C15H22N2
Molar mass	230.355 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CC)CCc1c(C)[nH]c2ccccc12;
	InChI InChI=1S/C15H22N2/c1-4-17(5-2)11-10-13-12(3)16-15-9-7-6-8-14(13)15/h6-9,16H,4-5,10-11H2,1-3H3; Key:VVUATPWGKMGHGM-UHFFFAOYSA-N;

2-Me-DET, or 2-methyl-DET, also known as 2-methyl-N,N-diethyltryptamine, is a psychedelic drug of the tryptamine family.^[1] It is the 2-methyl derivative of diethyltryptamine (DET).^[1] The drug is taken orally.^[1]

Use and effects

In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin lists 2-Me-DET's dose as 80 to 120 mg orally and its duration as 6 to 8 hours.^[1] The effects of 2-Me-DET have been reported to include a vague unreal feeling, clouding and slowing of thoughts, DiPT-like sound distortion including higher pitches of music sounding muffled and tones shifting to a lower frequency, and stomach ache.^[1]

Interactions

Pharmacology

Pharmacodynamics

2-Me-DET is a serotonin receptor agonist in the rat uterus and stomach strip, with similar potency as dimethyltryptamine (DMT) and diethyltryptamine (DET) but profoundly greater potency than 2-methyl-DMT.^[2]

Chemistry

Synthesis

The chemical synthesis of 2-Me-DET has been described.^[1]

Analogues

Analogues of 2-Me-DET include 2-methyltryptamine (2-MT; 2-Me-T), 2-methyl-DMT (2-Me-DMT; 2,N,N-TMT), 2-methyl-5-MeO-DMT (5-MeO-2,N,N-TMT), and 2-methyl-AMT (2-Me-AMT; 2,α-DMT).^[1]

History

2-Me-DET was first described in the scientific literature by R. B. Barlow and I. Khan in 1959.^[2] Subsequently, it was described in greater detail by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved).^[1]

References

1 2 3 4 5 6 7 8 9 10 Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
1 2 Barlow RB, Khan I (March 1959). "Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations". Br J Pharmacol Chemother. 14 (1): 99–107. doi:10.1111/j.1476-5381.1959.tb00934.x. PMC 1481812. PMID 13651585.

External links

[TiHKAL-1] 1 2 3 4 5 6 7 8 9 10 Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.

[BarlowKhan1959-2] 1 2 Barlow RB, Khan I (March 1959). "Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations". Br J Pharmacol Chemother. 14 (1): 99–107. doi:10.1111/j.1476-5381.1959.tb00934.x. PMC 1481812. PMID 13651585.

[1]

[2]